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Phosphatase Inhibitor Cocktail I effectively inhibits alkaline phosphatases and serine/threonine protein phosphatases such as PP1 and PP2A.
Phosphorylation of proteins and lipids is a hallmark of the signaling or metabolic status of cells. A cocktail of three inhibitors that will inhibit alkaline phosphatases as well as serine/threonine protein phosphatases such as PP1 and PP2A. Each vial contains 1 ml phosphatase inhibitor cocktail solubilized in DMSO with the following components: Bromotetramisole oxalate (2.5 mM), Cantharidin (500 µM), and Microcystin-LR , Microcystis aeruginosa (500 nM).
Phosphatase Inhibitor Cocktail I has been optimized and tested for mammalian cell and tissue extracts. This cocktail is supplied as a ready-to-use solution in DMSO.
Components
| Ingredient | M.W. | 100x Conc. | Target |
| (-)-p-Bromotetramisole oxalate | 995.2 | 2.5 mM | Alkaline phosphatases |
| Cantharidin | 373.2 | 500 μM | Ser/Thr phosphatases |
| Microcystin LR, Microcystis aeruginosa | 196.2 | 500 nM | PP1 and PP2A |
| Ingredient | M.W. | 100x Conc. | Target |
| Sodium Fluoride | 42.0 | 100 mM | Acid phosphatase |
| Sodium Orthovanadate | 183.9 | 100 mM | Alkaline phosphatases, PTPs, ATPases |
| Sodium Tartrate Dihydrate | 230.1 | 400 mM | Acid phsphatases |
| Sodium Molybdate | 205.9 | 115 mM | Acid and phosphoprotein phosphatases |
| Imidazole | 68.1 | 200 mM | Alkaline phosphatases |
